The Comparison of Teratogeiiic and Carcinogenic Effects of Some Carbamate Compounds
نویسنده
چکیده
Ethyl carbamate and a series of related compounds were given in single intraperitoneal doses to pregnant Syrian hamsters on Day 8 of gestation, and fetuses were examined for malformations on Day 13 of gestation. Urethan produced a variety of malforma tions and growth retardation. Of the compounds modified in the carboethoxy end, n-propyl carbamate was as teratogenic as the ethyl carbamate, and /3-hydroxyethyl carbamate had only bor derline effect, while allyl carbamate and n-butyl carbamate were completely negative. Four compounds modified in the cabamyl portion of the molecule were tested. Three of these, ethyl Nmethylcarbamate, ethyl .V-hydroxycarbamate, and diethylcarbonate, were teratogenic; a fourth, ethyl A',Ar-dimethyIcarbamate was not teratogenic. The ethyl A*-hydroxycarbamate
منابع مشابه
The comparison of teratogenic and carcinogenic effects of some carbamate compounds.
Ethyl carbamate and a series of related compounds were given in single intraperitoneal doses to pregnant Syrian hamsters on Day 8 of gestation, and fetuses were examined for malformations on Day 13 of gestation. Urethan produced a variety of malforma tions and growth retardation. Of the compounds modified in the carboethoxy end, n-propyl carbamate was as teratogenic as the ethyl carbamate, and ...
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